Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals through the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://peterf297cjr5.muzwiki.com/user