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Chemotherapy was potentiated by E7449 and single agent had considerable antitumor activity in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell traces, probable by way of TNKS inhibition. According to this risk, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and significantly altered expression https://bazedoxifene-acetate00987.like-blogs.com/29248731/examine-this-report-on-7-methylxanthine

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